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FLASH GENE
Symbol GMEB2 contributors: - updated : 10-09-2005
HGNC name glucocorticoid modulatory element binding protein 2
HGNC id 4371
DNA
TYPE functioning gene
STRUCTURE 32.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrinepancreas   highly
Lymphoid/Immunethymus   highly
Reproductivefemale systembreastmammary gland  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal KDWK domain, necessary for DNA binding
  • a SAND (DNA binding) domain
  • a highly acidic C terminus that likely forms a coiled-coil structure
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus glucocorticoid modulatory element binding protein
    intraspecies homolog to GMEB1
    Homologene
    FAMILY KDWK family of proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • modulator of transactivation by the glucocorticoid receptor, essential for parvovirus DNA replication
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of GMEB1 and GMEB2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding glucocorticoid receptor modulatory elements
  • may interact with CREB- binding protein (CBP)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS