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FLASH GENE
Symbol GDA contributors: - updated : 04-09-2007
HGNC name guanine deaminase
HGNC id 4212
DNA
TYPE functioning gene
STRUCTURE 102.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text four alternative splice variants (S,V1,V2,V3) (Kuwahara)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousbrain   highly
Reproductivefemale systemuterus  highly
Respiratorylung    
Urinarykidneytubuleconvoluted tubuleproximal tubule 
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
Text in developing dendrites
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a nine residue N terminal motif that is present in other aminohydrolases and amidohydrolases
  • zinc binding, collapsin response mediator protein (CRMP) homology domain
  • PSD-95, Discs large, zona occludens-1 binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila CG18143
    homolog to C.elegans T20D4.9
    homolog to rattus guanine aminohydrolase
    homolog to murine Gda guanine deaminase
    intraspecies homolog to CRMP1,weakly
    Homologene
    FAMILY ATZ/TRZ family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolytic deamination of guanine
  • producing xanthine and ammonia
  • may have a role in clustering neurotransmitter receptors
  • may influence synaptic development and plasticity by regulating postsynaptic protein sorting
  • regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly
  • decreases PSD-95 family member localization and regulates dendrite number
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis, synaptic development and plasticity
    PATHWAY
    metabolism nucleic , purine/pyrimidine
    signaling
    purine nucleotide catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+ (one ion per subunit)
    protein
  • regulating DLG4 (PSD-95) postsynaptin targeting
  • binds directly to tubulin heterodimers and promotes microtubule polymerization, via its CRMP homology domain to promote microtubule assembly
  • interacting with SNAPAP (coiled-coil domain (H2) of SNAPAP is required for GDA binding)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS