basic FUNCTION
| multi-C2 protein, presumably involved in Ca-dependent signaling events |
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functioning as Ca2+-regulated intrinsic membrane proteins with multiple C2 domains, expanding the repertoire of such proteins to a fourth class beyond synaptotagmins, ferlins, and MCTPs (multiple C2 domain and transmembrane region proteins) |
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endoplasmic reticulum (ER)-plasma membrane (PM) tethering function of ESYT1, ESYT2, ESYT3 (tricalbins in yeast) mediates the formation of ER-PM contacts sites, which are functionally distinct from those mediated by STIM1 and ORAI1 |
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implicated in the formation of junctions between endoplasmic reticulum and plasma membrane, as well as the Ca(2+) dependent replenishment of membrane phospholipids |
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implicated in the formation of endoplasmic reticulum (ER)-plasma membrane (PM) junctions and in the Ca(2+) dependent regulation of these junctions |
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ESYT2 recognizes a site in the upper kinase lobe of FGFR1 that is revealed by displacement of the kinase domain activation loop during receptor activation |
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is a presynaptic ER protein that can promote neurotransmission and synaptic growth, revealing the first neuronal functions of this conserved gene family |
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GRAMD2A, but not GRAMD1A, co-localizes with the ESYT2/ESYT3 tethers at ER-PM contacts in a PIP lipid-dependent manner |