basic FUNCTION
| involved in the base excision repair (BER) pathway, by catalysing the poly (ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture |
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and in DNA metabolism |
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being an essential element of the cell proliferation machinery, perhaps by functioning in the DNA repair pathways |
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required for the maintenance of genome stability |
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facilitating ATM-mediated activation of TP53 and promoting cellular resistance to ionizing radiation |
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may have a potential role in the regulation of gene expression |
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implicated in DNA damage response |
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bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation |
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recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage |
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implicated in DNA damage response |
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regulates TP53BP1-dependent signaling pathway following DNA damage |
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nuclear protein that is part of a histone H3K4 methyltransferase complex and is essential for embryonic development |
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role of PAXIP1 in maintaining embryonic stem cell pluripotency |
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promotes chromatin changes critical for immunoglobulin class switch recombination |
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importance of PAXIP1 in the DNA repair process associated with the development of mature spermatozoa |
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PAXIP1 status correlates with breast cancer staging, in a manner similar to what has been characterized for TP53BP1 |