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FLASH GENE
Symbol MSLN contributors: shn/npt - updated : 09-02-2013
HGNC name mesothelin
HGNC id 7371
DNA
TYPE functioning gene
STRUCTURE 8.10 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D16S521 - MSLN - D16S3024 - D16S3395 - cen
Physical map
SOLH 16p13.3 small optic lobes homolog (Drosophila) LOC146325 16p13.3 similar to hypothetical protein FLJ13841 FLJ36208 16p13.3 hypothetical protein FLJ36208 PIGQ 16p13.3 phosphatidylinositol glycan, class Q RAB40C 16p13.3 RAB40C, member RAS oncogene family WFIKKN 16p13.3 RAB40C, member RAS oncogene family MGC13114 16p13.3 hypothetical protein MGC13114 LOC388198 16 LOC388198 MGC15416 16p13.3 hypothetical protein MGC15416 KIAA1924 16p13.3 hypothetical protein KIAA1924 LOC197336 16p13.3 similar to RIKEN cDNA 3230401M21 [Mus musculus] ARHT2 16p13.3 ras homolog gene family, member T2 RHBDL1 16p13.3 rhomboid, veinlet-like 1 (Drosophila) STUB1 16p13.3 STIP1 homology and U-Box containing protein 1 LOC339123 16p13.3 similar to RIKEN cDNA 2610003J06 DKFZp434F054 16p13.3 hypothetical protein DKFZp434F054 MGC33974 16p13.3 hypothetical protein MGC33974 MGC2601 16p13.3 hypothetical protein MGC2601 MGC2494 16p13.3 hypothetical protein MGC2494 FLJ34512 16p13.3 hypothetical protein FLJ34512 HAGHL 16p13.3 hydroxyacyl glutathione hydrolase-like NARFL 16p13.3 nuclear prelamin A recognition factor-like MSLN 16p13.3 mesothelin RLUCL CHTF18 16p13.3 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) GNG13 16p13.3 guanine nucleotide binding protein (G protein), gamma 13 LOC388199 16 LOC388199 FLJ12681 16p13.3 hypothetical protein FLJ12681
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 2187 71 622 - 1996 8552591
17 - 2154 71 630 - 1996 8552591
18 - 2126 - 622 - 1996 8552591
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Reproductivefemale systemplacenta  lowly
Respiratorylung   highly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningmesothelium  
Membraneserous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal 33-AA signal sequence, and a region (296-359) consisting of 64 AAs at the N-terminal of cell surface mesothelin as the minimum fragment for complete binding activity to MUC16
  • four potential N-glycosylation sites
  • a MUC16-binding domain, significantly inhibiting cancer cell adhesion
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to Msln, Rattus norvegicus
    ortholog to Msln, Mus musculus
    ortholog to MSLN, Pan troglodytes
    Homologene
    FAMILY
  • mesothelin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • megakaryocyte potentiating factor
  • putatively involved in cell adhesion
  • enables cells to survive under anchorage-independent conditions by suppressing BCL2L11 induction via the extracellular signal-regulated kinase signaling pathway
  • cell surface glycoprotein that is overexpressed in human pancreatic cancer
  • activate PI3K (phosphoinositide 3-kinase)/Akt signalling and inhibit paclitaxel-induced apoptosis
  • MUC16 and mesothelin (MSLN), are associated with the invasion process in patients with pancreatic ductal adenocarcinoma
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between mesothelin (MSLN) and MUC16 may facilitate the implantation and peritoneal spread of tumors by cell adhesion
  • enhances ovarian cancer invasion by MMP7 expression through the MAPK/ERK and JNK signal transduction pathways
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    only in ovarian carcinoma and mesotheliomas
    tumoral     --over  
    promotes breast cancer cell invasiveness and metastasis
    tumoral     --over  
    by hypomethylation in malignant mesothelioma
    tumoral     --over  
    in human pancreatic cancer, leading to constitutive activation of STAT3, which results in enhanced expression of cyclin E and cyclin E/cyclin-dependent kinase 2 complex formation as well as increased G(1)-S transition
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker useful biomarker for breast cancer progression
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential new therapeutic agent for preventing or treating peritoneal malignant tumors
    cancerreproductivebreast
    novel therapeutic or chemopreventive target in human breast cancer
    ANIMAL & CELL MODELS
    mice disrupted for msln gen were viable, fertile and anatomically normal