basic FUNCTION
| having a principal function in both innate and adaptive immune responses |
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inactivating p38 and SAPK/SNK kinases |
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coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress |
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earlier unrecognized and non-redundant function in restraining MAPK14-mediated neutrophil oxidant production, thereby preventing LPS-induced vascular injury |
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with DUSP2, and DUSP1 are crucial players in the regulation of immune responses, but other members of the family, like the ERK-specific DUSP6, play a major role in development |
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key regulator in PYCARD-dependent MAPK activation |