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FLASH GENE
Symbol SPRR1A contributors: mct - updated : 16-05-2023
HGNC name small proline-rich protein 1A
HGNC id 11259
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered in the epidermal differentiation complex (EDC)
STRUCTURE 1.73 kb     1 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
text structure open reading frame in a single exon
MAPPING cloned Y linked   status confirmed
Map cen - SPRR4 - SPRR1A - SPRR3 - SPRR1B - SPRR2D - SPRR2A - SPRR2B - SPRR2E - SPRR2F - SPRR2C - SPRR2G - tel
Authors cabral et al.(01)
Text see S100A@ ,EDC@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 662 - 89 - 1997 9008234
2 - 648 - 89 - 1997 9008234
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage precursor of cornified cell envelope
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
small proline rich protein with a central segment built up from eight octapeptide repeats,*K*PEP*
HOMOLOGY
Homologene
FAMILY SPRR protein family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton
text cornifin
basic FUNCTION
  • involved in the differentiation of epidermal keratinocytes
  • SPRR proteins displayed potent bactericidal activity, exerting their bactericidal activity through binding and disruption of the bacterial membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component clustered in the epidermal differentiation complex (EDC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    significantly increased in atopic dermatitis (AD) skin
    tumoral     --over  
    significantly increased in colorectal cancer tissues compared with those in adjacent non-cancerous tissues, and associated with a significantly worse event- and relapse-free survival time
    tumoral     --over  
    associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a potential biomarker for the prognosis of colon cancer
  • may serve as a novel prognostic marker in pancreatic ductal adenocarcinoma (PDAC)
  • Therapy target
    ANIMAL & CELL MODELS