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FLASH GENE
Symbol STK38L contributors: mct/ - updated : 31-05-2014
HGNC name serine/threonine kinase 38 like
HGNC id 17848
DNA
TYPE functioning gene
STRUCTURE 81.42 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 5110 - 464 - 2004 1506700
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to Ndr protein kinase
Homologene
FAMILY
  • AGC Ser/Thr protein kinase family
  • NDR/LATS kinase family
  • CATEGORY enzyme , regulatory , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text excluded from the nucleus and exhibits a punctate cytoplasmic distribution
    basic FUNCTION
  • involved in the regulation of structural processes in differentiating and mature neuronal cells
  • might play a role in the HIV-1 life cycle
  • with STK38, are proapoptotic kinases and key members of the RASSF1/STK4 signaling cascade
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • STK24-STK38/STK38L-CDKN1A axis is an important regulator of G(1)/S progression of mammalian cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MOBKL1B
  • MOBKL1A
  • MOB2 is a negative regulator of STK38/STK38L in biochemical and biological settings
  • binds to and colocalizes with GTP-bound RAB11A and phosphatidylserine (PS) on pericentrosomal vesicles
  • STK38L-mediated RAB8A phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of RAB8A from phosphatidylserine (PS) to EXOC6, thereby promoting local activation of RAB8A and ciliary membrane formation
  • novel function of CCND1 in promoting cell cycle progression by enhancing STK38/STK38L kinase activity independent of CDK4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS