Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLXND1 contributors: mct/npt - updated : 28-11-2018
HGNC name plexin D1
HGNC id 9107
DNA
TYPE functioning gene
STRUCTURE 51.53 kb     36 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC166348 3q21.3 similar to RIKEN cDNA 4833415F11 SEC61A1 3q21.3 similar to RIKEN cDNA 4833415F11 RUVBL1 3q21 RuvB-like 1 (E. coli) SELB 3q21.3 elongation factor for selenoprotein translation LOC389146 3 LOC389146 DNAJB8 3q21.3 DnaJ (Hsp40) homolog, subfamily B, member 8 GATA2 3q21 GATA binding protein 2 LOC391572 3 similar to Transmembrane protein Tmp21 precursor (21 kDa Transmembrane trafficking protein) (p24delta) (S31III125) (S31I125) (Tmp-21-I) GR6 3q21 similar to Transmembrane protein Tmp21 precursor (21 kDa Transmembrane trafficking protein) (p24delta) (S31III125) (S31I125) (Tmp-21-I) FLJ40473 3q21.3 hypothetical protein FLJ40473 RPN1 3q21.3-q25.2 ribophorin I RAB7 3q21 RAB7, member RAS oncogene family LOC391573 3 similar to mKIAA1860 protein LOC391574 3 similar to MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase 4L; MARK4 serine/threonine protein kinase LOC389147 3 similar to WD repeat domain 10 isoform 3 LOC391575 3 similar to Fat-specific protein FSP27 homolog ACAD9 3q21.3 acyl-Coenzyme A dehydrogenase family, member 9 KIAA1257 3q21.3 KIAA1257 protein FLJ12057 3q21.3 hypothetical protein FLJ12057 GP9 3q21 glycoprotein IX (platelet) LOC339122 KIAA1160 3q21.3 KIAA1160 protein ZNF9 3p13.3-q24 zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) COPG 3q21.3 coatomer protein complex, subunit gamma DC12 3q21.3 DC12 protein H1FX 3q21.3 H1 histone family, member X LOC90288 3q21.3 hypothetical protein LOC90288 MBD4 3q21-q22 methyl-CpG binding domain protein 4 WDR10 3q21 WD repeat domain 10 RHO 3q21.3-q24 rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant) H1FOO 3q21.3 H1 histone family, member O, oocyte-specific PLXND1 3q21.3 plexin D1 KIAA0779 3q21.3 plexin D1 TRH 3q13.3-q21 thyrotropin-releasing hormone LOC391576 3 hypothetical gene supported by AK122996 LOC285407 3q21.3 similar to mannosyltransferase LOC339944 3q21.3 similar to hypothetical protein FLJ10661 LOC389148 3 LOC389148 FLJ35880 3q22.1 hypothetical protein FLJ35880 LOC131873 3q22.1 hypothetical protein LOC131873 PIK3R4 3q22.1 phosphoinositide-3-kinase, regulatory subunit 4, p150 GSTO3P1 3q22.1 glutathione S-transferase omega 3 pseudogene 1 ATP2C1 3q21 ATPase, Ca++ transporting, type 2C, member 1 HT001 3q22.1 HT001 protein NEK11 3q21.3 NIMA (never in mitosis gene a)- related kinase 11
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
36 - 6977 - 1925 - Tamagnone (1999)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SEMA homology domain
  • two typical and atypical cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS
  • a single transmembrane segment (1TM)
  • a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycling endosomes
  • HOMOLOGY
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion (Tamagnone 1999)
  • its expression during tumor development is strongly correlated with both invasive behavior and metastasis (Roodink 2008)
  • important role in directing migration of maturing thymocytes via modulation of biological responses to chemokine gradients (Choi 2008)
  • novel role of SEMA3E-PLXND1 function in modulating angiogenesis via a VEGFA-induced feedback mechanism (pMID: 21724832)
  • potential role of PLXND1 in cervical cancer-associated angiogenesis
  • PLXND1 operates in a cell context-specific fashion, mediating different synaptogenic outcomes depending upon neuron type
  • PLXND1 is a pivotal mediator of this signaling axis downstream of NOTCH in prostate cancer cells
  • PLXND1 signaling controls likely filopodium-like lateral protrusion (FLP) formation and the termination of neuronal migration through a precise control of microtubule dynamics.
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for the semaphorin 7A (SEMA7A)
  • semaphorin 3E (Sema3E), one of the ligands for PLXND1, has previously been correlated with invasive behavior and metastasis, suggesting that the PLXND1-SEMA3E interaction may play a role in tumor progression (Roodink 2008)
  • receptor of SEMA3E (interacting during the formation of proprioceptive sensory–motor reflex circuits) (Pecho-Vrieseling 2009)
  • SH3BP1 mediates SEMA3E-induced cell collapse through interaction with PLXND1 and regulation RAC1 activity
  • SEMA3E/PLXND1 modulates Immunological synapse (IS) formation and Ag-scanning activities of thymocytes within thymic tissues
  • mesenchymal SEMA3D guides outgrowth of the common cardinal vein via repulsion and signals through PLXND1
  • SEMA3G induces cell collapse in an NRP2/PLXND1-dependent manner
  • GIPC1-mediated endocytic trafficking regulates PLXND1 signaling, and PLXND1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic melanomas (Roodink 2008)
    tumoral       gain of function
    in melanoma, breast, colon, ovarian and prostate cancers
    constitutional germinal mutation      
    in PLXND1 and REV3L that are responsible for a proportion of Möbius syndrome (MBS) patients suggesting that de novo mutations in other genes might account for other MBS patients
    constitutional germinal mutation      
    in isolated truncus arteriosus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be a potential cervical cancer biomarker
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    NOTCH1-PLXND1 signaling axis may be targeted to impair prostate cancer cell invasiveness and metastasis
    ANIMAL & CELL MODELS
  • PlxnD1(-/-) mice exhibited defective germinal center (GC) reactions during T-dependent immune activation