basic FUNCTION
| G protein coupled receptor regulating endocrine function and puberty |
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essential for the development and maintenance of reproductive function in mammals |
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implicated in the regulation of pubertal and adulthood gonadotropin-releasing hormone (GnRH) secretion |
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necessary for proper male-like development of several sexually dimorphic traits, likely by regulating GNRH-mediated androgen secretion in perinatal development |
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playing with KISS1 a major role in the physiology of the gonadotrophic axis and as a relevant downstream element in the neuroendocrine network governing LH secretion |
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stimulates the hypothalamic-pituitary gonadal axis in males |
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key regulator of puberty and reproductive function |
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initiation and completion of reproductive maturation can occur in the absence of kisspeptin/GPR54 signaling |
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KISS1/KISS1R signaling is critical for regulating the activity of gonadotropin-releasing hormone (GNRH1) neurons in mammals |
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KISS1 is a metastasis suppressor gene of pancreatic cancer, and this suppression is not dependent on the expression levels of KISS1R |