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FLASH GENE
Symbol LANCL1 contributors: mct - updated : 28-03-2009
HGNC name LanC lantibiotic synthetase component C-like 1 (bacterial)
HGNC id 6508
DNA
TYPE functioning gene
STRUCTURE 45.46 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure within the potential promoter regions, several consensus sequences for ubiquitous and tissue-specific transcription factors are present (Mayer 2001)
MAPPING cloned Y linked   status confirmed
Map cen - D2S355 - D2S154 - CPS1 - MYL1 - LANCL1 - ERBB4 - D2S371 - D2S143 - FN1 - D2S137 - qter
Authors GeneMap (98)
RNA
TRANSCRIPTS type messenger
text Variants 1, 2 and 3 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4620 - 399 - Mayer (2001)
- - 4531 - 399 - -
- - 4526 - 399 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte
Blood/Hematopoieticmonocyte
Lymphoid/Immunelymphocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • seven transmembrane segments
  • seven highly conserved hydrophobic repeats
  • HOMOLOGY
    interspecies homolog to rattus Lancl1 (91.5 pc)
    homolog to murine Lancl1 (91.5 pc)
    homolog to a prokaryotic enzyme responsible for the synthesis of thioether (lanthionine) cross-linking within nascent polypeptide chains, yielding macrocyclic proteins with potent microbicidal activity (Chung 2007)
    Homologene
    FAMILY
  • G protein coupled receptor family
  • LanC-like protein family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the biosynthesis of antimicrobial peptides
  • glutathione binding protein possibly significant to neurodegenerative disease (Chung 2007)
  • may play a similar role as a peptide-modifying enzyme component in eukaryotic cells (Bauer 2000)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • G-protein coupled receptor protein signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the C-terminal of STOM
  • binding to low-density lipoprotein receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • SOD1G93A transgenic mice, a model for amyotrophic lateral sclerosis (ALS), wherein LanCL1 expression was found to be increased at presymptomatic stages of the disease (Chung 2007)
  • LANCL1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse (Nielsen 2003)