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FLASH GENE
Symbol ITGAX contributors: mct/npt - updated : 30-04-2010
HGNC name integrin, alpha X (complement component 3 receptor 4 subunit)
HGNC id 6152
DNA
TYPE functioning gene
STRUCTURE 27.81 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
30 - 4666 - 1163 - Wu (2010)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
cell lineage myeloid cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal large extracellular domain with a sevenfold repeated structure
  • putative cation-binding motifs in the three of four C terminal repeats
  • an I domain (UWF type A domain) inserted between the second and third repeats ligand binding, connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • beta(2)-integrin that plays an important role in T-cell accumulation and activation in adipose tissue, and contributes to insulin resistance associated with obesity (Wu 2010)
  • differential involvement of ITGAX and ITGAM in adhesion and subsequent cytoskeletal changes in monocytes exposed to different conditions indicates the importance of each integrin in distinct responses during inflammation (Georgakopoulos 2008)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    text phagocytosis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • dimerizing with ITGB2 in fibrinogen,receptor
  • forming with ITGB2 a leukocyte-specific integrin referred to i(C3b) receptor 4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by the proliferative state of the cell and tightly coupled to progression along the myeloid diferentiation pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic lupus erythematosus (SLE)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS