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FLASH GENE
Symbol SLC35A3 contributors: mct - updated : 09-04-2014
HGNC name solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
HGNC id 11023
DNA
TYPE functioning gene
STRUCTURE 58.02 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5886 - 325 - 1999 10393322
6 - 5633 - 220 - 1999 10393322
7 - 5721 - 367 - 1999 10393322
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 liver   highly
Reproductivefemale systemuterus  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans c03h5.2
intraspecies homolog to UDP-GALand CMP-sialic acid transporter
Homologene
FAMILY
  • solute carrier family 35
  • nucleotide sugar transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in nucleotide sugar transport in the Golgi apparatus
  • biological function of SLC35A2 and SLC35A3 in galactosylation of macromolecules may be coupled
  • SLC35A2 and SLC35A3 function in glycosylation is combined via their mutual interaction
  • regulates biosynthesis of highly branched N-glycans and keratan sulfate
  • major Golgi uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter 9)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC35A2 and SLC35A3 cooperate in the UDP-Gal delivery for glycosyltransferases located in the Golgi apparatus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMRS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS