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FLASH GENE
Symbol NUBP2 contributors: mct - updated : 29-04-2013
HGNC name nucleotide binding protein 2 (MinD homolog, E. coli)
HGNC id 8042
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1351 - 271 - Roy (2003)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systemovary  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain,lung,liver and kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal contributes to the morphology of the nucleus
  • ATP/GTP binding motif A phosphate binding (P loop)
  • NUBP/MPP alpha and beta motifs
  • HOMOLOGY
    interspecies ortholog to muirne Nubp2
    homolog to Drosophila CG4858
    Homologene
    FAMILY
  • PARA family ATPase
  • MRP/NBP35 family of ATP binding proteins
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • implicated with KIFC1 in a common regulatory pathway involved in the control of centrosome duplication in mammalian cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex with NUBP1, suggesting the existence of a heteromeric P-loop NTPase complex that is required for both cytosolic Fe/S protein assembly and cellular iron homeostasis
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS