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FLASH GENE
Symbol GINS1 contributors: mct/npt - updated : 25-08-2016
HGNC name GINS complex subunit 1 (Psf1 homolog)
HGNC id 28980
DNA
TYPE functioning gene
STRUCTURE 40.87 kb     7 Exon(s)
regulatory sequence Promoter
Binding site   transcription factor
text structure several consensus AML1, GATA, and Sry putative binding sequences are predicted within 5 kb of the putative transcription start site, and also binding sites for oncoproteins such as Myb and Ets (Han 2009)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3289 23 196 specifically expressed in spermatogonium stem cells Kamada (2007)
- - - - 190 present in primary and secondary spermatocytes Han (2009)
  • lacks 6 amino acid residues
  • may be unstable and degrade easily
  • - - - - 160 in primary and secondary spermatocytes Han (2009)
  • lacks a partial portion of a coiled-coil domain compared to the PSF1 protein
  • may be unstable and degraded easily
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two types of structural domains: an -helix rich (A) domain and a -strand rich (B) domain
  • N terminal region containing coiled-coil domain
  • a PR, central region containing arginine-rich domain (Han 2009)
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • GINS1/PSF1 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an essential role in the initiation of DNA replication
  • GINS complex playing an essential role in the initiation of DNA replication
  • having an essential role in the initiation and elongation phases of genome duplication
  • GINS complex is a key factor for establishing the initiation complex after prereplicative complex assembly and important for the normal progression of the replisome
  • replication complex that in S phase, associates first with replication origins and then with neighboring sequences (Takayama 2003)
  • essential for initiation of DNA replication and S phase progression and directly involved in cellular processes
  • necessary for proliferation and viability (Aparicio 2009)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the GINS complex which is a heterotetramer of SLD5, GINS1, GINS2 and PSF3
  • part of the the GINS complex, an integral component of the replicative helicase machinery that facilitates progression of the replisome complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact directly with the heterodimeric DNA primase
  • interacts with DNA replication factors MCM and CDC45 in chromatin during S phase (Aparicio 2009)
  • GINS1, GINS2, GINS3, GINS4 and TICRR compete with one another for MCM2-7 and CDC45 binding
  • cell & other
    REGULATION
    Other tightly regulated at the transcriptional level in stem cells (Han 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS