basic FUNCTION
| NDP- sugar hydrolase whose function is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates biochemical pathways in mouse |
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eliminating toxic nucleotides from the cell and regulating the levels of important signaling nucleotides and their metabolites |
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is an ADP-ribose (ADPR) pyrophosphatase (ADPRase) that plays important roles in controlling the intracellular levels of ADPR and preventing non-enzymatic ADP-ribosylation of proteins by hydrolyzing ADPR to AMP and ribose 5prime-phosphate |
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potentially eliminates various oxidized deoxyribonucleoside diphosphates from the nucleotide pool and prevents their toxic effects |
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has an intrinsic activity to cleave ADP sugars to AMP and sugar phosphate, possesses the ability to degrade 8-oxo-dGDP to the monophosphate |
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has the potential to prevent errors during DNA replication |
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hydrolyzes various modified nucleoside diphosphates including 8-oxo-dGDP, 8-oxo-dADP and ADP-ribose (ADPR) |
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may play significant roles in regulating the G1-S transition in mammalian cells |
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