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FLASH GENE
Symbol INSL6 contributors: mct/ - updated : 11-10-2017
HGNC name insulin-like 6
HGNC id 6089
DNA
TYPE functioning gene
STRUCTURE 21.75 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CARM1L 9p24.2 coactivator associated arginine methyltransferase 1-like RFX3 9p24 regulatory factor X, 3 (influences HLA class II expression) ZNF515 9p24.2 zinc finger protein 515 C9orf70 9p24.2 chromosome 9 open reading frame 70 SLC1A1 9p24 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 C9orf68 9p24.2 chromosome 9 open reading frame 68 HARC 9p24.1 chromosome 9 open reading frame 68 AK3L1 9p24.1-p24.3 adenylate kinase 3 like 1 LOC392282 9 similar to ribosomal protein S5 RCL1 9p24.1-p23 RNA terminal phosphate cyclase-like 1 JAK2 9p24 Janus kinase 2 (a protein tyrosine kinase) INSL6 9p24 insulin-like 6 INSL4 9p24.1-p23.3 insulin-like 4 (placenta) RLN2 9pter-q12 relaxin 2 (H2) RLN1 9pter-q12 relaxin 1 (H1) C9orf46 9p24.1 chromosome 9 open reading frame 46 PDCD1LG1 9p24 programmed cell death 1 ligand 1 PDCD1LG2 9p24.2 programmed cell death 1 ligand 2 KIAA1432 9p24.1 KIAA1432 KIAA1815 9p24 KIAA1815 MLANA 9p24.1 melan-A KIAA2026 9p24.1 KIAA2026 RANBP6 12p13.31 RAN binding protein 6 C9orf26 9p24.1 chromosome 9 open reading frame 26 (NF-HEV) LOC389704 9 similar to Selenoprotein T NYD-SP25 9p24.1 protein kinase NYD-SP25 NIRF 9p24.1 Np95-like ring finger protein C9orf38 9p24.1 chromosome 9 open reading frame 38 GLDC 9p24-p23 glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P) LOC392283 9 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC392284 9 hypothetical gene supported by AK091574 GASC1 9p24-p23 hypothetical gene supported by AK091574 LOC158352 9p24.1 similar to small nuclear ribonucleoprotein E
regionally located located near INSL4 and TDFA
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 711 250 213 - 2000 10819760
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
Reproductivesperm cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain conserved in all eukaryotes and predicted to consist of 1421 tandem HEAT-like (Huntingtin, Elongation factor 3, A subunit of protein phosphatase 2A, and Tor1) repeats
  • protein matching the classical signature of the insulin superfamily with B and A chain regions
  • a signal peptide, a B chain, a connecting C chain, and an A chain
  • a DNA-binding domain that resembles the alphaCTD domain of bacterial RNA polymerase alpha, and is required to resist replication stress
  • C-terminal domain with a DNA-binding domain and interacts with the BLM complex
  • HOMOLOGY
    interspecies homolog to murine Insl6
    homolog to C.elegans T08G5.3
    ortholog to rattus rat INSL6
    Homologene
    FAMILY
  • insulin family
  • insulin/IGF/relaxin family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    text
  • meiotic and postmeiotic germ cells of the testis are the principal sites of expression of INSL6
  • basic FUNCTION
  • having a role in sperm development and fertilization
  • required for the progression of spermatogenesis
  • confers a new DNA interface for the BLM complex to maintain normal replication
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
  • integral component of the BLM complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with the BLM complex through a conserved C-terminal domain, and the stability of Rif1 depends on the presence of the BLM complex
  • INSL6 is a novel CUL4B substrate in male germ cells, evidenced by its direct polyubiquination and degradation by CUL4B E3 ligase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    majority of the Insl6-deficient males on a hybrid genetic background exhibited impaired fertility, whereas females were fertile