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FLASH GENE
Symbol ACAA2 contributors: mct - updated : 30-08-2008
HGNC name acetyl-Coenzyme A acyltransferase 2
HGNC id 83
DNA
TYPE functioning gene
STRUCTURE 30.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D18S460 - [D18S1118 - D18S470 ] - D18S474 - qter
Authors Gene Map (98)
Text [ACAA2 ]
Physical map
MIZ1 18q12.1-q12.3 similar to 40S ribosomal protein S8 TCEB3L2 18q12,3 similar to 40S ribosomal protein S8 TCEB3L 18q21.1 similar to 40S ribosomal protein S8 DKFZP564D1378 18q21.1 hypothetical protein DKFZp564D1378 HSPC039 18q12 HSPC039 protein LOC390851 18 similar to RIKEN cDNA C230094B15 LOC201411 18q21.1 similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase) MADH2 18q21 MAD, mothers against decapentaplegic homolog 2 (Drosophila) LOC201501 18q21.1 similar to B230208J24Rik protein HEIL1 KIAA0427 18q21.1 KIAA0427 MADH7 18q21.1 MAD, mothers against decapentaplegic homolog 7 (Drosophila) FLJ20071 RPL17 18q21.1 ribosomal protein L17 LOC390852 18 similar to signal recognition particle 72kDa LIPG 18q21.1 lipase, endothelial ACAA2 18q21.1 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) MYO5B 18q12 myosin VB FLJ32743 18q21.1 hypothetical protein FLJ32743 MBD1 18q21 methyl-CpG binding domain protein 1 CGBP 18q12 methyl-CpG binding domain protein 1 MGC10200 18q21.1 hypothetical protein MGC:10200 LOC390853 18 similar to acidic ribosomal phosphoprotein P0 MAPK4 18q21.2-q21.3 mitogen-activated protein kinase 4 B29 18q21 mitogen-activated protein kinase 4 ME2 18q21 malic enzyme 2, NAD(+)-dependent, mitochondrial ELAC1 18q21 elaC homolog 1 (E. coli) MADH4 18q21.1 MAD, mothers against decapentaplegic homolog 4 (Drosophila) LOC51320 18q21.1 hypothetical protein LOC51320 LOC390854 18 similar to neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); Rho guanine nucleotide exchange factor (GEF) 8 LOC390855 18 similar to 40S ribosomal protein S8 DCC 18q21.1 deleted in colorectal carcinoma
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1952 41 397 - Cao (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinethyroid   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a non-cleavable amino-terminal targeting signal
  • HOMOLOGY
    Homologene
    FAMILY
  • thiolase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • acetyl-CoA acyltransferase 2, mitochondrial-3-oxoacyl-coenzyme A, thiolase, concluding the step of fatty acid beta oxidation
  • catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein functional BNIP3 binding partner (possible linkage between fatty acid metabolism and apoptosis of cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS