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FLASH GENE
Symbol YWHAQ contributors: mct/npt - updated : 11-01-2021
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
HGNC id 12854
DNA
TYPE functioning gene
STRUCTURE 47.03 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2196 - 245 - Leffers, Pereira-Faca (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
 thyroid   highly
Lymphoid/Immunelymph node   highly
Urinarybladder   highly
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone  highly
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • 14.3.3 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
  • multifunctional regulator
  • forms a molecular complex with HSPD1 and PRNP in the CNS under physiological conditions and this complex might become disintegrated in the pathologic process of prion diseases
  • participation of YWHAQ in the regulation of the placental epigenome that may participate in the molecular mechanisms that govern the pathological process of preeclampsia
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38 MAP kinase
  • interaction between CENPJ and 14-3-3, and this interaction appears to be phosphorylation and cell cycle dependent
  • binds SRPK2, which is regulated by Akt phosphorylation, and Akt phosphorylation also provokes SRPK2 nuclear translocation that is blocked by YWHAQ (Jang 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast lesion patients as compared with normal controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • differential expression of YWHAH, YWHAQ throughout brain regions of rats with insulin resistance