SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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text
| multi-pass membrane protein |
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at the Golgi, KDELR1, KDELR2 acts as a traffic sensor (presumably via binding to chaperones that leave the ER) and triggers signalling pathways that balance membrane fluxes between ER and Golgi |
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localize mainly to the Golgi-complex (usually cis-side), the endoplasmic reticulum (ER), and the intermediate ER-Golgi compartment (ERGIC) |
basic FUNCTION
| allowing the retrieval of proteins from Golgi complex to ER |
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mediating a retrieval mechanism contributing to quality control at the RE |
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required for the retention of luminal endoplasmic reticulum proteins |
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determining the specificity of the luminal ER protein retention system |
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required for normal vesicular traffic through the Golgi |
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KDELR2 competes with MV envelope proteins for binding to calnexin and HSPA5, and this interaction limits the availability of the chaperones for Measles Virus (MV) proteins, causing the reduction of virus spread and titers |
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KDELR1, KDELR2 regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover |