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FLASH GENE

Symbol

MAN1A2

contributors: mlc/np - updated : 02-11-2007

HGNC name	mannosidase, alpha, class 1A, member 2
HGNC id	6822

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	158.00 kb     13 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 13 - 5388 73 641 - Gregory (2006)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Endocrine neuroendocrine pituitary     highly Nervous brain         Reproductive female system placenta     highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a short cytoplasmic tail
	a single transmembrane segment (TM1)
	a large COOH-terminal catalytic domain
	a potential N glycosylation site

HOMOLOGY

interspecies

homolog to murine alpha1.2 Mannosidase 13

Homologene

FAMILY

glycosyl hydrolase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
text	type II transmembrane protein

basic FUNCTION	involved in processing of Asp-linked (N) glycans
	involved in hydrolysis of the terminal 1,2-linked alpha-D- mannose residues in the oligo-mannose oligosaccharide
	Man(9)(GlcNAc)(2)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	Ca2+

protein

cell & other

REGULATION

inhibited by

both 1-deoxymannojirimycin and kifunensine

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS