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FLASH GENE
Symbol ITGB1 contributors: mct - updated : 26-10-2015
HGNC name integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HGNC id 6153
DNA
TYPE functioning gene
STRUCTURE 58.05 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • putative HOXD1-binding sites in the promoter region of ITGB1
  • MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    text with alternatively spliced isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 3879 88.4 798 - 2002 11779688
  • also called variant 1A
  • a 16 exons variant
  • an alternate 5'UTR due to the use of the alternate proximal promoter
  • containing exon 16b (shorter than 16a)
  • containing exon 19a (longer than 19b & 19c)
  • lacking exons 2, 17 & 18
  • encoding the same isoform as variant 1E
  • 16 splicing 3739 88.9 801 - 2002 11779688
  • also called variant 1D
  • a 16 exons variant
  • containing exon 16b (shorter than 16a)
  • containing exon 19b
  • lacking exons 1, 2 & 18
  • containing a unique 24 aa carboxy terminus
  • 16 splicing 3794 88.4 798 - 2002 11779688
  • also called variant 1E
  • a 16 exons variant
  • an alternate 5'UTR, due to the use of an alternate distal promoter
  • containing exon 16b (shorter than 16a)
  • containing exon 19c (shorter than 19a & 19b)
  • lacking exons 1, 17 & 18
  • encoding the same isoform as variant 1A
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestivemouth   moderately
    Endocrineparathyroid   moderately
    Hearing/Equilibriumearinnercochlea moderately
    Reproductivefemale systemuterus  moderately
     male systemprostate  lowly
    Respiratoryrespiratory tracttrachea  highly
    Visualeye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   highly
    Connectivebone  moderately
    Epithelialbarrier lining  lowly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell
    cell lineage epidermal cells of the basal layer (stem, transit-amplifying, commited basal cells)
    cell lines Schwannomas
    fluid/secretion
    at STAGE
    physiological period embryo
    Text umbilical cord and embryonic tissue at an higly level
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 20 amino acids signal peptide (2,2 kDa)
  • a globular domain
  • a stalk region with several EGF-like repeats each with eight cysteine residues
  • a single transmembrane (TM) and a short cytoplasmic tail
  • a von Willebrand factor (VWF) type A domain
  • mono polymer heteromer , dimer
    isoforms Precursor a 778 amino acids mature peptide (86,2 kDa)
    HOMOLOGY
    interspecies homolog to rattus Itgb1 (90.60 pc)
    homolog to murine Itgb1 (91.23 pc)
    intraspecies homolog to ITGB2
    Homologene
    FAMILY
  • integrin beta chain family
  • CATEGORY adhesion , antigen , signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text coexpressed in prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B)
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • inhibitor of cell proliferation
  • involved in migration and survival in primary oligodendrocytes
  • dispensable for the initiation of ERBB2 tumor induction, it plays a critical role in metastatic phase of tumor progression
  • essential for normal wound healing, where it acts, at least in part, through a TGFBeta-dependent mechanism
  • critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory
  • required both for fibroblast chemotaxis towards platelet-derived growth factor (PDGF) and growth factor-induced dorsal ruffling
  • SEMA7A on keratinocytes and ITGB1 on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, such as psoriasis or wound
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    text promoting a cell migratory phenotype in association with PRKCA
    PATHWAY
    metabolism
    signaling
  • ITGB1-WNT7A-DCN pathway promotes proliferation and differentiation of neuroepithelial cells, and identify DCN as a novel neurogenic factor in the central nervous system
  • a component
  • dimerizing with ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV (see symbols)
  • complexing with PRKCA
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeting ERM proteins, MSN, RDX, EZR in association with PRKCA
  • YWHAB
  • associate with insulin-like growth factor type 1 receptor (IGF-IR) and regulate IGF-stimulated prostate cancer cell proliferation
  • interacting with RET (can activate ITGB1, and that RET-induced cell adhesion and migration require ITGB1)
  • ITGB1 is a transcriptional target of HOXD1 in endothelial cells
  • SERPINB5 physically associates with both PLAUR and ITGB1, thus producing a complex that regulates both cell motility and adhesion
  • TLN1 binds to ITGB1 cytoplasmic tails and regulates integrin activation
  • PML regulates endothelial cell migration, in part, by modulating expression of downstream genes, such as ITGB1
  • NELL1 binds to extracellular ITGB1 and induces cell focal adhesion
  • SOX10 and ITGB1 interaction in enteric neural crest cell migration
  • ARAP2 and ACAP1 had opposing effects on apparent ITGB1 internalization
  • RAB23 promotes squamous cell carcinoma cells migration and invasion by regulating ITGB1/TIAM1/RAC1 pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
  • dysregulation of protein expression
  • coexpressed in human prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B)
  • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS