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FLASH GENE

Symbol

TMEM59

contributors: shn - updated : 31-01-2011

HGNC name	transmembrane protein 59
HGNC id	1239

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	21.76 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D1S509 - D1S266 - TMEM59 - D1S417 - D1S2652 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004872 8 - 1709 NP_004863 - 323 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a minimal 19-AA peptide in its intracellular domain that promotes LC3 labelling and lysosomal targeting of its own endosomal compartment, and may facilitate the search for adaptor proteins that promote selective autophagy by engaging ATG16L1

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to Tmem59, Mus musculus
	ortholog to TMEM59, Pan troglodytes
	ortholog to Tmem59, Rattus norvegicus

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

intracellular,cytoplasm,organelle,Golgi

basic FUNCTION

a modulator of amyloid precursor protein shedding

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with ATG16L1 and mediates autophagy in response to Staphylococcus aureus infection

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS