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FLASH GENE
Symbol MYBPH contributors: mct - updated : 21-05-2012
HGNC name myosin binding protein H
HGNC id 7552
DNA
TYPE anonymous DNA segment
STRUCTURE 8.01 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1806 - 477 - 1994 7881442
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouthtongue   
Endocrineparathyroid    
Reproductivemale systemprostate  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two immunoglobulin-like C2-type domains
  • two fibronectin type III domains, and one fibronectin type III domain was required for MYBPH binding to MYH9
  • HOMOLOGY
    interspecies ortholog to murine Mybph
    homolog to rattus Mybph
    homolog to zebrafish Dr.7502
    homolog to C.elegans T06D4.1
    Homologene
    FAMILY
  • immunoglobulin superfamily, MYBP subfamily
  • CATEGORY adhesion , motor/contractile , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the regulation of striated muscle contraction
  • may be involved in interaction with thick myofilaments in the a-band
  • MYBPH is a transcriptional target of the TTF1 lineage-survival oncogene and plays a crucial role in inhibition of cancer cell motility, invasion, and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • structural constituent of muscle
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to myosin and to thick myofilaments in the A-band
  • MYBPH directly interacts with an additional molecule, MYH9, which was found to occur between MYBPH and the rod portion of MYH9
  • MYBPH inhibited MYH9 assembly and reduced cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS