SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| intracellular,nucleus,nucleolus
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| recruited to the proximal ends of centrioles through a number of mechanisms including microtubule-dependent and independent pathways and association with cytoplasmic particles |
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concentrated at the proximal ends of centrioles, and also localises to the distal portion of the mother centriole |
basic FUNCTION
| functioning as a serine/threonine kinase |
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playing a role at the G2-M transition |
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playing a role in meiosis |
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regulating centrosome cohesion and separation through phosphorylation of structural components of the centrosome |
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involved in biological processes of the Golgi body, perhaps in relation to the inheritance of Golgi during mitosis or to cell cycle stage-specific regulation of exocytosis |
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interacts with MXD1 at the kinetochore and possibly functions as a novel integrator of spindle checkpoint signaling |
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NEK2-mediated phosphorylation of SGOL1 provides a link between centromeric cohesion and spindle microtubule |
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kinetochore-associated protein kinase essential for faithful chromosome segregation and regulating kinetochore microtubule attachment stability |
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increased NEK2 activity disrupts the interaction of CROCC and centrosomes, resulting in binding of beta-catenin to CROCC-independent sites on centrosomes, an event that is required for centrosome separation) |
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play a pivotal role in tumorigenic growth of breast carcinoma cells |
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may act upon the MAD2L1-CDC20 protein complex and play a critical role in regulating the mitotic checkpoint protein complex |
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involved in the phosphorylation of NDC80 that modulates chromosome alignment and signaling of the spindle assembly checkpoint |
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might bear a close relationship with development and progression of breast carcinoma |
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has a role in promoting cilium disassembly at the onset of mitosis |
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NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response |
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in contrast to NEK2, KIF18A is not degraded until anaphase showing that additional mechanisms contribute to NEK2 degradation |