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FLASH GENE
Symbol ZNF124 contributors: npt - updated : 21-12-2009
HGNC name zinc finger protein 124
HGNC id 12907
DNA
TYPE functioning gene
STRUCTURE 16.12 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2080 - 296 - Miyake,Saleh
also called HZF16
4 - 1674 - 289 in hematopoietic progenitor cells, increased after VEGF stimulation Saleh
  • also called ZK7
  • may inhibit apoptotic cell death in HNSCC.
    		•
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Kruppel-associated box A-box domain at the NH2 terminus
  • seven ZNF motifs at the COOH terminus
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be involved in the inhibitory effect of VEGF on apoptotic cell death in human hematopoietic cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS