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FLASH GENE
Symbol FGD2 contributors: mct - updated : 06-01-2011
HGNC name FYVE, RhoGEF and PH domain containing 2
HGNC id 3664
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 23.42 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 3045 - 655 - 2007 17564959
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
 tonsils    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/Immunedendritic cell Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • adjacent RhoGEF and PH domains
  • a second carboxy-terminal PH domain
  • a distinctive FYVE domain, conserved domain for endosomal localization
  • C-terminal pleckstrin homology domain mediates recruitment to membrane ruffles
  • HOMOLOGY
    intraspecies homolog to FGD1
    Homologene
    FAMILY
  • small subfamily of predicted RhoGEFs
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microfilament
    text complex intracellular localization, with concentrations found in membrane ruffles and early endosomes, sole member of the characterized Fgd family that can localize to early endocytic vesicles
    basic FUNCTION
  • may be playing a role in embryonic development
  • playing a role in leukocyte signaling and vesicle trafficking in cells specialized to present antigen in the immune system
  • may have a role in the regulation of cell polarization and migration, since membrane ruffles often form at the leading edge of migrating cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role of FGD2 in the activation of Cdc42 and not of Rac1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS