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FLASH GENE
Symbol OAZ2 contributors: mct - updated : 26-06-2012
HGNC name ornithine decarboxylase antizyme 2
HGNC id 8096
DNA
TYPE functioning gene
STRUCTURE 15.70 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1936 - 189 - 1999 10352227
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • ornithine decarboxylase antizyme 2, negative regulator of polyamine level
  • controling the intracellular concentration of polyamines
  • catalyzing the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis
  • regulate ornithine decarboxylase (ODC), which is involved in polyamine synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its synthesis requires a polyamine-induced translation frameshift which links open reading frame 1 (ORF1) with open reading frame 2 (ORF2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated with increased survival and with several favorable clinical neuroblastoma characteristics
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS