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FLASH GENE
Symbol GNAL contributors: mct/npt - updated : 03-01-2017
HGNC name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
HGNC id 4388
DNA
TYPE functioning gene
STRUCTURE 195.73 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 6048 44.2 381 - 2000 11032382
12 - 4027 44.2 381 expressed in D1-rich areas of the brain (Laurin 2008) 2000 11032382
  • localized at the perinuclear region and causes large endosome formation
  • N-terminal region plays an important role in perinuclear localization, Golgi localization and endosome formation
  • interacting with RAB3A, and RAB8A
  • couple to the adenosine A2A receptor (ADORA2A)(Ravyn 2006)
  • 12 - 6491 52.3 458 - 2000 11032382
    13 - 5850 - 381 - 2000 11032382
    8 - 5568 - 174 - 2000 11032382
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrineneuroendocrinepituitary  highly
    Hearing/Equilibriumear   highly
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialsensoryolfactory  
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GTPase domain made of three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • G-alpha family
  • G(s) subfamily
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • alpha stimulating activity, olfactory type
  • involved as modulators or transducers in various transmembrane signaling systems
  • may be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters
  • GNAL-encoded protein is important for dopamine D1 receptor function and odorant signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heteromeric G protein complex, with 3units: alpha, beta and gamma
  • the alpha chain contains the guanine nucleotide binding site
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DYT25
    Susceptibility
  • to bipolar disorder and schizophrenia
  • possible contribution in the susceptibility to ADHD, with possible involvement of parent-of-origin effects (Laurin 2008)
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS