Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol USP33 contributors: mct/npt - updated : 13-03-2018
HGNC name ubiquitin specific peptidase 33
HGNC id 20059
DNA
TYPE functioning gene
STRUCTURE 63.89 kb     24 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
motif
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 4551 107 942 - 2011 21801292
  • USP33 T1
  • 24 - 4372 103 911 . insert within the catalytic domain, required for association with the endoplasmic reticulum 2011 21801292
  • USP33 T2
  • 23 - 2956 - 828 marked accumulation at the Golgi apparatus 2011 21801292
  • second insert is required for membrane association, but can be alternatively spliced (variant 3) to excise eight amino acids, which otherwise suppress Golgi localization
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ZnF UBP domain
  • a protein module found in many proteins in the ubiquitin-proteasome system, that does not bind to ubiquitin (Allen 2007)
  • HOMOLOGY
    interspecies homolog to murine Vdu1
    Homologene
    FAMILY
  • peptidase C19 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • would be involved in ubiquitin-dependent protein catabolism
  • deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein and also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase (Allen 2007)
  • player in Slit-Robo signaling in cancer cell migration and required for Slit responsiveness in breast cancer cells (Yuasa-Kawada 2009)
  • required for Slit-induced Robo1 relocation to the plasma membrane (Yuasa-Kawada 2009)
  • role in vertebrate commissural axon guidance and in SLIT1 signaling (Yuasa-Kawada 2009)
  • required for SLIT1 responsiveness of commissural neurons (Yuasa-Kawada 2009)
  • USP33 and USP20 coordinate ADRB2 recycling and resensitization
  • is a deubiquitinase that has been associated with a variety of physiological events
  • USP33 potently and specifically deubiquitinates CCP110, but not other cyclin-F substrates
  • is a previously unknown tumor-suppressing gene for colorectal cancer (CRC) by mediating the inhibitory function of Slit-Robo signaling on CRC cell migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with VHL (target for ubiquitination and degradation by pVHL E3 ligase)
  • interacting with SELENBP1 (Jeong 2009)
  • interacts with ROBO1 and is required for Slit-induced ROBO1 redistribution to the plasma membrane without affecting the total ROBO1 protein level (Yuasa-Kawada 2009)
  • USP33 interacts with CCP110 and localizes to centrioles primarily in S and G2/M phases, the periods during which centrioles duplicate and elongate
  • HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33
  • ubiquitination by the E3 ligase NEDD4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regulate the lysosomal trafficking and recycling of agonist-activated ADRB2
  • BTRC interacted with USP33 independently of the classic binding motif for BTRC, and mediated USP33 degradation via the ubiquitin proteasome pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in multiple cohorts of lung cancer patients and low expression of USP33 is associated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • independent prognostic biomarker for papillary thyroid carcinoma (PTC), low USP33 expression indicated high recurrence risk
  • potential value of USP33 as an independent prognostic marker of colorectal cancer (CRC)
  • Therapy target
    ANIMAL & CELL MODELS