SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm
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basic FUNCTION
| would be involved in ubiquitin-dependent protein catabolism |
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deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein and also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase (Allen 2007) |
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player in Slit-Robo signaling in cancer cell migration and required for Slit responsiveness in breast cancer cells (Yuasa-Kawada 2009) |
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required for Slit-induced Robo1 relocation to the plasma membrane (Yuasa-Kawada 2009) |
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role in vertebrate commissural axon guidance and in SLIT1 signaling (Yuasa-Kawada 2009) |
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required for SLIT1 responsiveness of commissural neurons (Yuasa-Kawada 2009) |
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USP33 and USP20 coordinate ADRB2 recycling and resensitization |
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is a deubiquitinase that has been associated with a variety of physiological events |
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USP33 potently and specifically deubiquitinates CCP110, but not other cyclin-F substrates |
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is a previously unknown tumor-suppressing gene for colorectal cancer (CRC) by mediating the inhibitory function of Slit-Robo signaling on CRC cell migration |