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FLASH GENE
Symbol PLCL2 contributors: mct - updated : 15-01-2018
HGNC name phospholipase C-like 2
HGNC id 9064
DNA
TYPE functioning gene
STRUCTURE 287.92 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3964 - 1001 - 1999 10581172
- - 4170 - 1127 - 1999 10581172
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Reproductivefemale systemplacenta  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C2 domain
  • an EF-hand domain
  • a PI-PLC X-box domain
  • a PI-PLC Y-box domain
  • HOMOLOGY
    interspecies homolog to murine Plcl2,phospholipase C-like 2
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in signal transduction pathways
  • PLCL1, PLCL2, are likely positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS