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FLASH GENE
Symbol NLGN1 contributors: mct/pgu - updated : 11-12-2009
HGNC name neuroligin 1
HGNC id 14291
DNA
TYPE functioning gene
STRUCTURE 885.87 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389176 3 similar to Histone-lysine N-methyltransferase, H4 lysine-20 specific (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7) PHC3 3q26.32 polyhomeotic like 3 (Drosophila) PRKCI 3q26.3 protein kinase C, iota SKIL 3q26 SKI-like CLDN11 3q26.2-q26.3 claudin 11 (oligodendrocyte transmembrane protein) FLJ37228 3q26.31 hypothetical protein FLJ37228 KIAA1613 3q26.31 KIAA1613 protein LOC391591 3 similar to ribosomal protein L28; 60S ribosomal protein L28 LOC200916 3q26.31 similar to RIKEN cDNA 3110001N18 EIF5A2 3q25-q27 eukaryotic translation initiation factor 5A2 SLC2A2 3q26.2-q26.3 solute carrier family 2 (facilitated glucose transporter), member 2 KIAA0551 3q26.31 Traf2 and NCK interacting kinase PLD1 3q26 phospholipase D1, phophatidylcholine-specific LOC389177 3 LOC389177 FAD104 3q26.31 FAD104 LOC391592 3 similar to basic leucine zipper and W2 domains 1 GHSR 3q26.2 growth hormone secretagogue receptor TNFSF10 3q26 tumor necrosis factor (ligand) superfamily, member 10 LOC339858 3q26.31 similar to High-affinity copper uptake protein 1 (hCTR1) (Copper transporter 1) KIAA1363 3q26.31-q26.32 KIAA1363 protein ECT2 3q26.1-q26.2 epithelial cell transforming sequence 2 oncogene RNU4P4 3q26.32 RNA, U4 small nuclear pseudogene 4 NYD-SP12 3q26.32 NYD-SP12 protein NLGN1 3q26.32 neuroligin 1 LOC344666 3q26.32 similar to 60S ribosomal protein L8 LOC254827 3q26.32-q26.33 hypothetical protein LOC254827
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 4918 - 823 - 2009 19730411
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain   highly
Reproductivefemale systemovary  lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain lowly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal specific interaction with the GOPC PDZ domain
  • extracellular domain sufficient to induce assembly of functional presynaptic terminals, while the intracellular domain was required for terminal maturation
  • HOMOLOGY
    interspecies homolog to rattus neuroligin 1
    Homologene
    FAMILY
  • neuroligin (Nlgn) family of postsynaptic transmembrane proteins
  • type-B carboxylesterase/lipase family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text post synaptic
    basic FUNCTION
  • mediating cell to cell interactions between neurons
  • triggering presynaptic development in contacting axon
  • induces apparent synapse formation by binding to presynaptic alpha-neurexins
  • essential role for presynaptic terminal maturation
  • also involved in critically controls key steps of presynaptic bouton maturation
  • performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities
  • with CDH2, cooperate to control vesicle clustering at nascent synapses
  • postsynaptic adhesion protein that control the maturation and function of synapses in the central nervous system (CNS)
  • NLGN1 and NLGN2 are essential for excitatory and inhibitory synaptic functions
  • postsynaptic cell-adhesion protein specific for excitatory synapses, which shares a high degree of similarity with acetylcholinesterase
  • acts as a nucleating factor during the APP aggregation process, stimulating the formation of APP oligomers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text formation and remodeling of central nervous system synapses
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • beta neurexins
  • interacting with GOPC (GOPC interacts with many other proteins, such as the Wnt receptors Frizzled 8 and neuroligin via its PDZ domain)
  • cooperation of CDH2 and NLGN1 via the postsynaptic scaffolding web is required to transsynaptically induce presynaptic vesicle clustering
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS