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FLASH GENE
Symbol AAK1 contributors: mct/npt/pgu - updated : 11-07-2009
HGNC name AP2 associated kinase 1
HGNC id 19679
DNA
TYPE functioning gene
STRUCTURE 185.85 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 21283 93.6 961 - 2007 17494869
- - - - - - 2007 17494869
contains an extended C-terminus that encodes an additional clathrin-binding domain (CBD2) consisting of multiple low-affinity interaction motifs
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • serine/threonine kinases family, Ark/Prk family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • as a regulator of clathrin-mediated endocytosis
  • may be specifically activated in coated pits to enhance cargo recruitment and efficient internalization
  • atypical kinase that is rate limited by its stable association with TFAP2A
  • functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome
  • key endocytic kinase, regulating NUMB endocytic activity
  • could play a positive role in early NOTCH1 endocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • interacting with NUMB (redistributes NUMB to perinuclear endosomes when overexpressed, while kinase depletion causes NUMB to accumulate at the plasma membrane)
  • directly interacts with the membrane-tethered active form of NOTCH1 released by metalloprotease cleavage
  • cell & other
    REGULATION
    activated by clathrin (efficient stimulation by clathrin involves multiple interactions between several domains on AAK1 and both heavy and light chains on clathrin)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS