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FLASH GENE
Symbol RAD54B contributors: mct/npt - updated : 01-06-2011
HGNC name RAD54 homolog B (S. cerevisiae)
HGNC id 17228
DNA
TYPE functioning gene
STRUCTURE 103.12 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • INO80 binds to the promoters of the RAD54B and XRCC3 genes
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3057 103 910 - 2002 11884632
    - - 3097 - 726 - 2002 11884632
    - - 1156 - 117 - 2002 11884632
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal region outside the SWI2/SNF2 domain that shares less conservation with the corresponding region in RAD54, and plays multiple roles of in homologous recombination
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD54P
    homolog to murine Rad54l
    intraspecies homolog to RAD54L
    paralog to RAD54
    Homologene
    FAMILY
  • SNF2/RAD54 helicase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text formed nuclear foci that colocalized with RAD51, RAD54, and BRCA1
    basic FUNCTION
  • participating in homologous recombination pathway (HR)
  • DNA and RNA helicase
  • mitotic and meiotic recombinaition and double-strand break repair
  • may function with the DMC1 recombinase, a meiosis-specific RAD51 homolog
  • may stimulate the DMC1-mediated DNA strand exchange by stabilizing the nucleoprotein filament, which is formed on the ssDNA tails produced at DSB sites during homologous recombination
  • DNA-dependent ATPase, described to be involved in recombinational repair of DNA damage, including DNA double-strand breaks (DSBs)
  • plays important roles in homologous recombination
  • synergizes with the DMC1 recombinase to mediate inter-homologue recombination during meiosis
  • CELLULAR PROCESS nucleotide, repair, recombination
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex formation between RAD54B and DMC1 and enhancement of the recombinase activity of DMC1 by RAD54B
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific interaction between S100A11 and RAD54B
  • S10A11 targets RAD54B to sites of DNA DSB repair sites and have a novel function in CDKN1A-based regulation of cell cycle
  • interacting with DMC1 (RAD54B binding may affect the quaternary structure of DMC1)
  • interacting with XRCC3 genes, implicated in DSB repair, to be repressed by INO80 deficiency
  • interacting with INO80 (binds to the promoters of the RAD54B and XRCC3 genes)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    homozygously mutated in primary lymphoma and colon cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS