basic FUNCTION
| coactivator of AR mediated transactivation in prostate, effect inhibited by a RNF14 (ARA54) dominant negative mutation |
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androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation |
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playing a role in the regulation of cyclin D1 expression in the absence of AR stimulation in cancer cells |
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might participate in enhancing cell cycle progression and cell proliferation via induction of cyclin D1 (CCND1)(Kikuchi 2007) |
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androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation (Kikuchi 2007) |
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may play an important role in testicular development and spermatogenesis in humans (Lan 2008) |