SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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| intracellular,nuclear envelope
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text
| cytosolic and colocalizing with COPB1 in a perinuclear structure probably with Golgi membranes |
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GBF1 acts at the cis-Golgi, whereas ARFGEF1 and its close paralog ARFGEF2 act at the trans-Golgi |
basic FUNCTION
| activators of ADP-ribosylation factor GTPases that are essential for regulating vesicular traffic among intracellular organelles |
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preferentially activates ADP-ribosylation factor 1 (ARF1) and ARF3 |
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also involved in nuclear functions |
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required for correct glycosylation and function of integrin beta1 and playing a role in cytoskeletal dynamics through integrin-beta1-mediated signaling |
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ARFGEF1, ARFGEF2 play redundant roles in trafficking between the TGN and endosomes that involves the AP-1 complex |
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ARFGEF1 is required to maintain the normal morphology of the Golgi but ARFGEF2 is important for endosomal compartment integrity and cannot replace the function of ARFGEF1 in Golgi organization |
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effects of ARFGEF1 and KANK1 proteins on cell polarity and directed migration during wound healing |
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Arf guanine nucleotide-exchange factors ARFGEF1, ARFGEF2 and regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex |