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FLASH GENE
Symbol ARFGEF2 contributors: mct - updated : 09-04-2014
HGNC name ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
HGNC id 15853
DNA
TYPE functioning gene
STRUCTURE 114.98 kb     39 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
40 - 9004 - 1785 - 2005 15705715
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Endocrinepancreas    
Nervousbrain    
 spinal cord   highly
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation
  • HOMOLOGY
    interspecies homolog to Drosophila CG7187
    intraspecies homolog to BIG1
    Homologene
    FAMILY
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • colocalizing with COPB1 in a perinuclear structure probably with Golgi membranes
  • GBF1 acts at the cis-Golgi, whereas ARFGEF1 and its close paralog ARFGEF2 act at the trans-Golgi
  • basic FUNCTION
  • playing an important role in vesicular and membrane trafficking from the trans-golgi network
  • involved in the activation of ARFs (ARF1, ARF5 and ARF6) by accelerating replacement of bound GDP with GTP
  • activator of ADP-ribosylation factor GTPases that are essential for regulating vesicular traffic among intracellular organelles
  • ARFGEF1, ARFGEF2 play redundant roles in trafficking between the TGN and endosomes that involves the AP-1 complex
  • ARFGEF1 is required to maintain the normal morphology of the Golgi but ARFGEF2 is important for endosomal compartment integrity and cannot replace the function of ARFGEF1 in Golgi organization
  • alone or in concert with recruited MYCBP coordinates ARF-mediated membrane trafficking and signaling pathways
  • may coordinate actin cytoskeleton mechanics and membrane traffic in cell migration via ITGB1 action and actin functions
  • involved in the activation of ARFs by accelerating replacement of bound guanosine diphosphate (GDP) with Guanosine triphosphate (GTP), and is involved in Golgi transport
  • Arf guanine nucleotide-exchange factors ARFGEF1, ARFGEF2 and regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    text Golgi transport
    PATHWAY
    metabolism
    signaling
    a component
  • component with BIG1 of a macromolecular complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EXOC7 in trans-golgi network and centrosome
  • ARL1 is necessary for Golgi recruitment of ARFGEF1 and ARFGEF2 but not GBF1
  • regulates filamin A phosphorylation and neuronal migration
  • GBF1-activated ARFs (ARF4 and ARF5, but not ARF3) facilitate ARFGEF1 and ARFGEF2 recruitment to the trans-Golgi network (TGN)
  • FLNA regulates neuronal migration through ARFGEF2-dependent ARF1 activation
  • cell & other
    REGULATION
    inhibited by brefeldin A
    ASSOCIATED DISORDERS
    corresponding disease(s) ARPHM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    significantly up-regulated in the Huntington disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS