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FLASH GENE
Symbol CCL26 contributors: mct - updated : 05-12-2008
HGNC name chemokine (C-C motif) ligand 26
HGNC id 10625
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 2.02 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure a binding site for STAT6
MAPPING cloned Y linked N status confirmed
Physical map
GTF2IRD2 7q11.23 transcription factor GTF2IRD2 LOC389522 7 similar to Cohesin subunit SA-3 (Stromal antigen 3) (SCC3 homolog 3) PMS2L5 7q11-q22 postmeiotic segregation increased 2-like 5 LOC389523 7 similar to opposite strand transcription unit to Stag3; Gats protein WBSCR16 7q11.23 Williams-Beuren syndrome chromosome region 16 LOC389524 7 similar to transcription factor GTF2IRD2 NCF1 7q11.23 neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1) LOC392058 7 similar to opposite strand transcription unit to Stag3; Gats protein PMS2L2 7q11-q22 postmeiotic segregation increased 2-like 2 LOC222190 7q11.23 hypothetical gene supported by AK024602 DKFZP434A0131 7q11.23-q21.1 DKFZp434A0131 protein TRIM50B 7q11.23 tripartite motif-containing 50B WBSCR20B 7q11.23 tripartite motif-containing 50B LOC340318 7q11.23 hypothetical protein LOC340318 PMS2L9 7q11.23 postmeiotic segregation increased 2-like 9 HIP1 7q11.23 huntingtin interacting protein 1 CCL26 7q11.23 chemokine (C-C motif) ligand 26 CCL24 7q11.23 chemokine (C-C motif) ligand 24 LOC392059 7 similar to ALY NPD007 7q11.23 NPD007 protein POR 7q11.2 P450 (cytochrome) oxidoreductase TMPIT 7q11.23 transmembrane protein induced by tumor necrosis factor alpha MK-STYX 7q11.23 map kinase phosphatase-like protein MK-STYX MDH2 7cen-q22 malate dehydrogenase 2, NAD (mitochondrial) LOC389525 7 similar to hypothetical protein LOC285908 LOC392060 7 similar to GrpE protein homolog 1, mitochondrial precursor (Mt-GrpE#1) (HMGE) LOC392061 7 similar to GTF2I repeat domain containing 1 isoform 2; Williams-Beuren syndrome chromosome region 11; GTF2I repeat domain-containing 1; general transcription factor 3; muscle TFII-I repeat domain-containing protein 1 alpha 1 FLJ37078 7q11.23 hypothetical protein FLJ37078 HSPB1 7q11.23 heat shock 27kDa protein 1 YWHAG 7q11.23 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide LOC392062 7 similar to peptidylprolyl isomerase A SRCRB4D 7p12.3 scavenger receptor cysteine rich domain containing, group B (4 domains) ZP3 7q11.23 zona pellucida glycoprotein 3 (sperm receptor) DTX2 7p12.3 deltex homolog 2 (Drosophila) UPK3B 7q11.2 uroplakin 3B POMZP3 7q11.23 POM (POM121 homolog, rat) and ZP3 fusion LOC392063 7 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) LOC370523 7q11.23 similar to deltex 2 LOC389526 7 hypothetical gene supported by AK024602 LOC389527 7 similar to PMS4 homolog mismatch repair protein - human LOC202802 7q11.23 similar to Williams Beuren syndrome chromosome region 19 FGL2 7q11.2 fibrinogen-like 2
regionally located tightly linked to SCYA24
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1800 - - . highly in heart and liver . lowly in skeletal muscle and kidney Guo
4 - 562 - 94 . lowly in heart, liver, skeletal muscle and kidney Guo, Lee (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinesmall intestine   
 liver   predominantly
Reproductivefemale systemovary  lowly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
a 23 amino acid signal peptide
secondary structure an unstructured N terminus before the first two conserved Cys, an irregularly structured N-loop following the second conserved cys, a single turn of 3(10)-helix, a three stranded antiparallel beta-sheet, an alpha-helix and an unstructured C terminal tail
mono polymer monomer
HOMOLOGY
interspecies homolog to C.elegans y116f11b.1
homolog to Drosophila eg:bacr25b3.3
Homologene
FAMILY intercrine beta family
CATEGORY immunity/defense , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • lymphocyte chemoattractant (chemotractive for eosinophils and basophils)
  • acting as a CCR3 ligand
  • inhibiting CCL2 -mediated responses, thus acting as a natural antagonist for CCR2 and exerting a repulsive effect on monocytes
  • first chemokine that features broadband antagonistic activities, suggesting that it may have a modulatory rather than an inflammatory function
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS inflammation
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling signal transduction
    cell to cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to receptor CCR3
  • antagonizing CCR1, CCR2, CCR5
  • CREB1 gene silencing decreased IL13-induced transcription of eotaxin-3 (CCL26)
  • cell & other
    REGULATION
    induced by IL13 and IL14 in HUVECand IL4
    Other regulated by STAT6 (in dermal fibroblasts)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma and total IgE dosage
    Variant & Polymorphism SNP 77C > T, +716A > G, EOT 3 +1579G > A increasing the risk of asthma
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergy  
    CCR3 and CCR5 receptor/ligand signaling pathways may be important targets for development of novel mechanism-based adjunctive therapies designed to abrogate the chronic inflammation associated with airway diseases
    ANIMAL & CELL MODELS