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FLASH GENE
Symbol HLX contributors: mct - updated : 01-10-2009
HGNC name H2.0-like homeobox
HGNC id 4978
DNA
TYPE functioning gene
STRUCTURE 5.66 kb     4 Exon(s)
text structure a GCC repeat
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2308 50 488 - Slavotinek (2009)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunespleen   highly
Reproductivefemale systemuteruscervix highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebonesubchondral  
Epithelialbarrier liningendometrium  
cell lineage hematopoietic lineages
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text extra-embryonic tissues, such as placenta, eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
  • a stretch of alanine
  • HOMOLOGY
    interspecies homolog to Drosophila antennapedia
    Homologene
    FAMILY
  • H2.0 homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • putative transcription factor involved in embryogenesis and hematopoiesis
  • may be playing an important role in lymphocytes and certain developing tissues
  • required for the transcriptional control of genes important for endometrial cell differentiation
  • may potentially function to balance attractive with repulsive vessel guidance by up-regulating UNC5B and to down-modulate sprouting under normoxic conditions
  • strongly increased the transcripts for several repulsive cell-guidance proteins including UNC5B, PLXNA1, and SEMA3G
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by vascular endothelial growth factor-A (VEGFA) in endothelial cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to congenital diaphragmatic hernia
    Variant & Polymorphism other variants increasing risk of congenital diaphragmatic hernia ((Slavotinek 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS