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FLASH GENE
Symbol APLP1 contributors: mct/npt - updated : 10-12-2018
HGNC name amyloid beta (A4) precursor-like protein 1
HGNC id 597
DNA
TYPE anonymous DNA segment
STRUCTURE 11.30 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure
  • TP53 responsive element found in the first intron of the APLP1 gene locus (tang 2007)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2450 - 651 - Neumann, Kaden (2009)
    17 - 2447 - 650 - Neumann, Kaden (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     pancreas   highly
    Nervousbrainforebraincerebral cortex  
     braindiencephalonhypothalamus highly
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular and a cytoplasmic domains
  • a NPXY sequence motif found in many tyrosine- phosphorylated proteins is required for the specific binding of the PID domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • Alzheimer's amyloid precursor protein (APP)family
  • CATEGORY secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type 1 membrane protein
  • mainly localizes to the cell surface (Kaden 2009)
  • basic FUNCTION
  • may be playing a role in postsynaptic function
  • can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I
  • putative specific role of APLP1 in cell adhesion (Kaden 2009)
  • a key modulator of the cellular stress response, inducing cell-cycle arrest, apoptosis, senescence and cell differentiation (Tang 2007)
  • TP53-dependent induction of APLP1 is involved in neural cell death, and which may exacerbate neuronal cell loss in some acute or chronic neurodegenerative disorders (Tang 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • copper
  • protein
  • may interact with cellular G-protein signaling pathways
  • transcriptional target of TP53 (Tang 2007)
  • regulation mechanism of CACNA1E surface expression, which implicates APLP1 as a regulator of calcium homeostasis
  • cell & other
    REGULATION
    induced by induced in senescent cells in a TP53-dependent manner (tang 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    likewise stimulates neurite lengthening (Young-Pearse 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS