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FLASH GENE
Symbol GDF3 contributors: mct - updated : 15/10/2008
HGNC name growth differentiation factor 3
HGNC id 4218
DNA
TYPE functioning gene
STRUCTURE 5.98 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1224 41.3 364 - -
  • a 114 aa mature peptide of 12.9kda
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
     thymus    
    Reproductivemale systemtestis  lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    cell lineage
    cell lines human embryonal carcinoma cell lines in a stem cell-specific fashion
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 24 aa signal peptide
  • TGF beta-like domain
  • TGF beta propeptide (LAP)
  • conjugated GlycoP
    mono polymer homomer , heteromer , dimer
    isoforms Precursor cleaved at a consensus Arg-X-XArg to yield a C terminus mature dimer
    HOMOLOGY
    interspecies homolog to rattus Gdf3 (68.9 pc)
    homolog to murine Gdf3 (71.2 pc)
    Homologene
    FAMILY
  • TGF-beta family
  • BMP (bone morphogenetic protein) family
  • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • playing a role in the regulation of adult lymphatic and erythroid systems
  • regulating the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types of embryonic stem cells
  • functional complementarity between GDF1 and GDF3 during embryonic development
  • important and evolutionarily conserved role for GDF3 in oculo-skeletal development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CRIPTO (CRIPTO acts as an obligate coreceptor for transforming growth factor beta (TGF-beta) ligands, including nodals, growth and differentiation factor 1 (GDF1, and GDF3)
  • cell & other
    REGULATION
    activated by cleaved by subtilisin like convertases
    ASSOCIATED DISORDERS
    corresponding disease(s) KFS3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS