Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | GDF3 | contributors: mct - updated : 15/10/2008 |
HGNC name | growth differentiation factor 3 |
HGNC id | 4218 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 5.98 kb 2 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
|
tissue |
|
cells |
|
cell lineage
cell lines
| human embryonal carcinoma cell lines in a stem cell-specific fashion | fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
|
conjugated | GlycoP |
mono polymer | homomer , heteromer , dimer |
isoforms | Precursor | cleaved at a consensus Arg-X-XArg to yield a C terminus mature dimer |
HOMOLOGY |
interspecies | homolog to rattus Gdf3 (68.9 pc) |
homolog to murine Gdf3 (71.2 pc) |
Homologene |
FAMILY | |
|
CATEGORY | signaling cytokine growth factor |
SUBCELLULAR LOCALIZATION | extracellular |
text | secreted |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | development |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
activated by | cleaved by subtilisin like convertases |
ASSOCIATED DISORDERS |
corresponding disease(s) | KFS3 |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
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| |
ANIMAL & CELL MODELS |