Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FGF18 contributors: mct/npt/pgu - updated : 11-04-2017
HGNC name fibroblast growth factor 18
HGNC id 3674
DNA
TYPE functioning gene
STRUCTURE 37.51 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • containing putative Tcf4-binding motifs
  • two transcription pathways that are essential for bone, physically and functionally converge at the promoter (direct interactions of Runx2 and canonical Wnt signaling induce FGF18)
  • a GLIS3 binding site in the FGF18 promoter flanking region is important in its regulation by GLIS3
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1546 - 207 - 1998 9742123
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Reproductivefemale systemovary   
    Respiratorylung    
    Skin/Tegumentskin appendageshair    Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text developing tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • typical hydrophobic signal sequence at N terminus
  • HOMOLOGY
    interspecies homolog to rattus FGF18
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF8 subfamily
  • CATEGORY RNA associated , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • signaling molecule inducing osteoclast formation through receptor activator of nulear receptor NFKB ligand and PTGS2 resembling to FGF2 and stimulating the proliferation of chondrocytes
  • regulate the growth plate chondrocyte proliferation, hypertrophy and cartilage vascularization necessary for endochondral ossification
  • may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth
  • perichondrial FGF1, FGF2, FGF6, FGF7, FGF9, FGF18, FGF21, FGF22 regulate growth plate chondrogenesis
  • induction of hepatic and intestinal proliferation
  • repressing noggin gene induction and thereby increased chondrocyte gene expression and chondrogenesis by facilitating bone morphogenetic protein-dependent signals
  • required for embryonic lung alveolar development
  • FGF18 and FGFR3 are involved, possibly as partners, in the control of intestinal precursor cell proliferation
  • provided both directional and proliferative cues to chondrocytes in the developing upper respiratory tract (exerted this effect on developing chondrocytes by up-regulating SOX9 expression)
  • enhancing cell migration in response to mechanical damage
  • seems to play a role in maintenance of chondrocyte properties, although its expression was rather high in dedifferentiated chondrocytes
  • novel regulatory mechanism for FGF18 signaling involving GLG1 and DLK1
  • epithelial FGF18 signaling and its reduction in the milieu of hair stem cells are crucial for the maintenance of resting and growth phase, respectively
  • pleiotropic protein that stimulates proliferation in several tissues
  • could be used to improve bone repair and regeneration
  • FGF8, FGF17 and FGF18 are required for closure of the embryonic ventral body wall
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RPS15A/FGF18 pathway may be a rational target for anti-angiogenic therapy of hepatocellular carcinoma (HCC)
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of the WNT signaling pathway
  • interacting with RUNX2
  • interacting with perlecan (perlecan can bind FGF18 and alter the mitogenic effect of FGF18 on growth plate chondrocytes)
  • direct target of canonical Wnt signaling
  • ligand of FGFR3
  • overexpression of WDR5 in the perichondrium promotes chondrocyte differentiation by modulating the expression of TWIST1 and FGF18
  • GLG1 is involved in FGF18 signalling via FGFR3C
  • plasma membrane binding of FGF8, and most likely of the FGF8 family members FGF17 and FGF18, to CUBN improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity
  • FOXP1 regulates the quiescent stem cell state in the hair follicle stem cell niche by controlling FGF18 expression
  • cell & other
    REGULATION
    activated by calcineurin-dependent transcription factor, NFAT4 (nuclear factor of activated T-cell 4)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal tumours and is progressively enhanced during colon carcinogenesis reaching very high levels in carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Fgf-18 null mice exhibit a skeletal dwarfism similar to that of perlecan null mice