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FLASH GENE
Symbol KIF20A contributors: - updated : 12-06-2003
HGNC name kinesin family member 20A
HGNC id 9787
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   HRE
text structure CDE-CHR element in the promoter
MAPPING cloned Y linked N status confirmed
Map cen - D5S500 - CDC25C - EGR1 - FGF1 - HARS - D5S2119 - D5S402 - D5S406 - qter
Authors GeneMap (98)
regionally located in the smallest commonly
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
 thymus   highly
Cardiovascularheart   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Lymphoid    
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
cell cycle     cell cycle, M
Text tissues highly placenta lowly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a motor domain and an ATP catalitic domain,hallmarks of kinesin like proteins,in the N terminus
HOMOLOGY
interspecies homolog to murine Rab6kifl
Homologene
FAMILY kinesin like protein kinase family
CATEGORY motor/contractile , signaling , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text in later stages of mitosis,localized to the spindle mid-zone
basic FUNCTION
  • acting as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules
  • crucial role in late anaphase B and/or cytokinesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein GTP bound forms of RAB6A and RAB6B
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS