Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | SLC12A7 | contributors: mct/npt - updated : 09-06-2021 |
HGNC name | solute carrier family 12 (potassium/chloride transporters), member 7 |
HGNC id | 10915 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 61.68 kb 24 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
---|
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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|
EXPRESSION |
Type |
tissue |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | embryo |
Text | periventricular zone, cranial nerves and choroid plexus |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
| |
|
HOMOLOGY |
interspecies | homolog to murine Slc12a7 |
homolog to C.elegans H16O14.1 |
intraspecies | homolog to SLC12A4 |
homolog to SLC12A6 |
Homologene |
FAMILY | |
|
CATEGORY | transport carrier |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | expressed in the gastric parietal cells more abundantly at the luminal region of the gland than at the basal region (Fujii 2009) |
basic FUNCTION | |
| |
| |
| |
|
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | active transport |
text | potassium/chloride-cotransporter |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
| |
cell & other |
REGULATION |
activated by | IGF1 (plays an important role in IGF1 receptor signaling to promote growth and spread of breast cancer cells) (Hsu 2007) |
Other | regulated in vascular endothelial cells by EGF |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
|
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |
Kcc4 -/- mice (Boettger,2002) |