basic FUNCTION
| ADP-ribosyltransferase (NAD+,poly ADPribose polymerase)-like 3 |
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involved in the base excision repair (BER) pathway, by catalysing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism |
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may link the DNA damage surveillance network to the mitotic fidelity checkpoint |
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negatively influences the G1/S cell cycle progression without interfering with centrosome duplication |
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involved in detection/signaling pathway leading to the reparation of DNA strand breaks |
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nuclear protein involved in transcriptional silencing and in the cellular response to DNA damage  |
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molecular roles for PARP3 and APLF in chromosomal DNA double-strand break repair reactions (  |
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catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory  |
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particular role of PARP3 in cellular response to double-strand breaks, most likely in concert with PARP1  |
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