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FLASH GENE

Symbol

PARP3

contributors: mct - updated : 28-06-2011

HGNC name	poly (ADP-ribose) polymerase family, member 3
HGNC id	273

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.52 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001003931 11 splicing 2355 variant 1 60 540 - 2011 21211721 NM_005485 11 splicing 2360 variant 2 60 533 - 2011 21211721 containing an additional segment in the coding region using a downstream start codon, compared to variant 1 encoding the same isoform than variant 3 variant 3 - splicing 2490 variant 3 60 532 - 2011 21211721 encoding the same isoform than variant 2 containing an additional segment in the coding region using a downstream start codon, compared to variant 1

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus     moderately Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	the N-terminal domain composed of 54 amino acids is responsible for its centrosomal localization
	the catalytic domain in the C-terminal region

conjugated

RiboP , Other

HOMOLOGY

interspecies

ortholog to murine Adprtl3

intraspecies

homolog to ADPRT

Homologene

FAMILY

ARTD(PARP) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	core component of the centrosome
	preferentially localized to the daughter centriole throughout the cell cycle

basic FUNCTION	ADP-ribosyltransferase (NAD+,poly ADPribose polymerase)-like 3
	involved in the base excision repair (BER) pathway, by catalysing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism
	may link the DNA damage surveillance network to the mitotic fidelity checkpoint
	negatively influences the G1/S cell cycle progression without interfering with centrosome duplication
	involved in detection/signaling pathway leading to the reparation of DNA strand breaks
	nuclear protein involved in transcriptional silencing and in the cellular response to DNA damage
	molecular roles for PARP3 and APLF in chromosomal DNA double-strand break repair reactions (
	catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory
	particular role of PARP3 in cellular response to double-strand breaks, most likely in concert with PARP1

CELLULAR PROCESS

nucleotide, repair

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

auto-poly(ADP)-ribosylation

INTERACTION

DNA

binding

RNA

small molecule

protein	interaction between PARP1 and PARP3 is unrelated to DNA single-strand break repair
	interacting with APLF (molecular roles for PARP3 and APLF in chromosomal DNA double-strand break repair reactions)

cell & other

REGULATION

activated by

DNA double-strand breaks (DSBs) and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate chromosomal DNA DSB repair

induced by

DNA breaks

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS