basic FUNCTION
| maybe involved in interaction between activated T lymphocytes and endothelial cells |
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activating NF-kappa B via TNFR-associated factor 2 (TRAF2) and NF-kappaB inducing kinase (NIK) |
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modulating T lymphocyte survival in peripheral tissues |
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regulator of osteoclast generation and substantiate the major role played by the endothelium in bone physiology |
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may play important role in ocular immunity |
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TNFSF18 utilizes multiple oligomerization states to regulate TNFRSF18-mediated signaling during T cell costimulation |
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TNFRSF18, but also TNFSF18 is capable of transducing signals, and the consequences of TNFRSF18-TNFSF18 interaction may vary among different effector cell types, differ upon signal transduction via the receptor, the ligand, or both, depend on the level of an ongoing immune response |
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could promote Th17 cell differentiation by MAPK14 and STAT3 signaling in autoimmune arthritis |