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FLASH GENE
Symbol IL16 contributors: mct/ - updated : 21-06-2006
HGNC name interleukin 16 (lymphocyte chemoattractant factor)
HGNC id 5980
DNA
TYPE functioning gene
STRUCTURE 115.90 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
Binding site   transcription factor
text structure two promoter elements (one constitutive and another inducible) both promoters contain two CAAT box like motifs and three binding sites of GA-binding portein (GA BP) transcription factors
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 6077 66.5 631 - -
18 - 8065 141.6 1332 - -
19 - 8322 - 1331 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneactivated B lymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two PDZ/DHR domains
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Il16
    homolog to C.elegans F59a3.8
    Homologene
    FAMILY
    CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inducing the chemotactic and immunomodulatory responses of CD4+lymphocytes
  • monocyte, eosinophil and lymphocyte chemoattractant factor
  • modulating T-cell activation and replication of HIV
  • inducing T-lymphocyte expression of interleukine two receptor
  • involvement of the IL16 precursor molecules in myosin-based contractile processes, most likely in cell motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling
    cell to cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD4 receptor
  • cell & other
    REGULATION
    induced by GABP alpha and beta
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS