protein
| mediating in connection with TRADD, the entry of TRAF6 into the LMP1 (oncogenic latent membrane protein 1 of the Epstein-Barr virus)-complex |
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implicated in TNF mediated activation of (NF kappaB) in association with MAPK8 |
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recruiting BIRC2, BIRC3 to TNFR2 (TNFRSF1B) |
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TRAF3 |
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interacting with TNFSF14 and LTBR (plays a critical, nonredundant role in TNFSF14-LTBR signaling) |
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E3 ubiquitin ligase SMURF2 is a TRAF2 binding protein |
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interacting with SMURF2 and TNFRSF1B (SMURF2-induced TNFRSF1B ubiquitination and subcellular relocalization of TNFRSF1B and TRAF2 enables the specific activation of the JNK pathway) |
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rapidly binds to the IFNAR1 subunit of the IFN receptor upon IFN binding (role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response) |
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MAPKBP1 interacted with not only NR2C2, but also with its upstream regulators, TNF-receptor associated factors 2 and 6 (TRAF2 and TRAF6) |
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binds to sphingosine kinase 1 (SPHK1), one of the isoenzymes that generates the pro-survival lipid mediator sphingosine-1-phosphate (SGPP1) inside cells |
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intracellular target of SGPP1 |
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interacting wiuth TRPC4AP (region between AAs 249 and 440 is also important for the interaction between TRPC4AP and TRAF2) |
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STUB1 regulates NFKB1-mediated cell invasion via the down-regulation of TRAF2 |
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BIRC2, BIRC3 and the adaptor protein TRAF2 interacted with caspase-1-containing complexes |
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interacting with USP4 that is a deubiquitinase targeting TRAF2 and TRAF6 for deubiquitination |
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TRAF2-mediated ubiquitin shutoff timer that inactivates CASP8 to exert crucial control over cell-extrinsic apoptosis |
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RAD23A down-regulated TRAF2 protein level through ubiquitin–proteasome system |
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overexpression of TRAF2 augmented the cytoplasmic expression of TRAF4 which promoted cell proliferation and inhibited cell apoptosis by activating NFKB nuclear transcription) |
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TRAF2 is critical for either TNFRSF1A- or TNFRSF1B-mediated activation of NFKB and mitogen-activated protein kinase (MAPK) signaling, as well as for target gene expression |
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TNFSF12 inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes |
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its expression is negatively regulated by the full-length isoform of TRAF3 as formation of a MAP3K14-TRAF3-TRAF2 complex targets MAP3K14 for degradation |
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HACE1 is essential for the ubiquitylation of the adaptor protein TRAF2 and formation of the apoptotic CASP8 effector complex |
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HOXA1 binds RBCK1 and TRAF2 and modulates the TNF/NFKB1 pathway in a transcription-independent manner |
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XAF1 interacts with TRAF2 and inhibits TRAF2-dependent NFKB1 activation, in part, by blocking TRAF2 polyubiquitination |
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TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals mediated by TNFSF13B receptor |