Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAP2K6 contributors: SGE/npt - updated : 14-09-2018
HGNC name mitogen-activated protein kinase kinase 6
HGNC id 6846
DNA
TYPE functioning gene
STRUCTURE 127.63 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CACNG5 17q24 calcium channel, voltage-dependent, gamma subunit 5 CACNG4 17q24 calcium channel, voltage-dependent, gamma subunit 4 CACNG1 17q24 calcium channel, voltage-dependent, gamma subunit 1 HELZ 17q24.2 helicase with zinc finger domain PSMD12 17q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 PITPNC1 17q24.3 phosphatidylinositol transfer protein, cytoplasmic 1 DKFZP586L0724 17q24.3 DKFZP586L0724 protein LOC253924 17q24.3 similar to 60S ribosomal protein L17 (L23) FALZ 17q24 fetal Alzheimer antigen LOC284018 17q24.3 hypothetical protein LOC284018 LOC390809 17 similar to KIAA0563 protein LOC388413 17 similar to PP905 LOC51321 17q24.3 hypothetical protein LOC51321 SLC16A6 17q25.1 solute carrier family 16 (monocarboxylic acid transporters), member 6 KIAA1001 17q23-q24 solute carrier family 16 (monocarboxylic acid transporters), member 6 FLJ10055 17q24.3 hypothetical protein FLJ10055 PRKAR1A 17q23-q24 protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) FAM20A 17q24.3 family with sequence similarity 20, member A ABCA8 17q24 ATP-binding cassette, sub-family A (ABC1), member 8 ABCA9 17q24 ATP-binding cassette, sub-family A (ABC1), member 9 ABCA6 17q24.2 ATP-binding cassette, sub-family A (ABC1), member 6 ABCA10 17q24 ATP-binding cassette, sub-family A (ABC1), member 10 ABCA5 17q21-q25 ATP-binding cassette, sub-family A (ABC1), member 5 MAP2K6 17q23.1-q24.2 mitogen-activated protein kinase kinase 6 LOC388414 17 LOC388414 LOC388415 17 LOC388415 KCNJ16 17q23.1-q21.2 potassium inwardly-rectifying channel, subfamily J, member 16 KCNJ2 17q23.1-q24.2 potassium inwardly-rectifying channel, subfamily J, member 2 LOC390810 17 similar to calmodulin - rabbit (tentative sequence) LOC124685 17q25.1 similar to smooth muscle and non-muscle myosin alkali light chain isoform 1 LOC388416 17 LOC388416 SOX9 17q24.3-q25.1 SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
RNA
TRANSCRIPTS type messenger
text several alternatively spliced isoforms, with distinct tissue expression (Han)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1879 - 334 skeletal muscle, heart, liver, pancreas Inoue (2005)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a docking site, a stretch of about 20 amino acids immediately on the C-terminal side of the MAPKK catalytic domain (Takekawa 2005)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map2k6
    homolog to C.elegans R03g5.2
    intraspecies homolog to MAP2K3
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serine/threonine kinase, controlling cell proliferation (cell cycle arrest)
  • involved in TNFA mediated endothelial SCYA2 (MCP1) expression
  • involved in BMP4-stimulated osteocalcin synthesis, as a positive regulator in osteoblasts
  • activating PRKMK8 and p38 kinase (MAPK) and required for ABL1 induced apoptosis
  • downregulates NADPH oxidase activity by enhancing Rac-GTPase activity (Harraz 2007)
  • with MAP3K7, constitute the p38 signalling pathway to participate to Osteoclasts differentiation by TNFSF11 through p65 phosphorylation and NFATC1 induction (Huang 2006)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38-dependent mRNA stabilization of 42 AU rich genes, some involved in macrophage activation
  • inducing SOCS3
  • stress activated kinase MAP2K6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure
  • cell & other
    REGULATION
    activated by UV, anisomycin and os miotic stock
    phosphorylation
    TNFA
    Other phosphorylated by MAP3K5 (Sturchler 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS