SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,cytosolic,vesicle
|
text
| type II transmembrane protein |
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cytosolic membrane anchored |
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localizing to ribbon-associated synaptic vesicles in hair cells |
basic FUNCTION
| multi-C2 domain protein, putatively involved in synaptic vesicular trafficking and vesicle membrane fusion |
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is essential for a late step of synaptic vesicle exocytosis and may act as the major Ca(2+) sensor triggering membrane fusion at the inner hair cell ribbon synapse |
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could be a part of components contributing to trans-Golgi trafficking |
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C2 domain-containing Ca2+-binding protein, implicated as having a role in vesicular release |
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involved in replenishing synaptic vesicles |
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confers the high capacity for vesicle re-supply to the inner hair cell synapse |
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potentially, endowing vesicle supply at the inner hair cell synapse with high Ca2+ sensitivity to enable sufficient vesicle replenishment during weak stimulation |
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ferlins are calcium-sensing proteins and are candidate mediators of vesicle-plasma membrane fusion during myoblast fusion |